Metabolites are the byproducts of a substance after it has run through your system. To determine whether you will pass or not, it is important to know how much of the illicit metabolites are in your urine and how much is tested for.
Drugs that do not need TDM: Drugs that used for treating diseases of which their clinical end points can easily be monitored, e. Drugs whose serum concentrations do not correlate with therapeutic or toxic effects.
Drugs with less complicated pharmacokinetics. Aminoglycosides - Gentamicin, Amikacin: Others - Vancomycin 3.
Phenobarbital, Phenytoin, Carbamazepine, Valproate 6. Narrow therapeutic range 3. Poor relationship between dose and serum drug concentrations SDC 4. Lack of therapeutic effects is dangerous 7.
Difficulty in interpreting signs and symptoms of toxicity or therapeutic failure or in evaluating therapeutic responses: Toxicity vs therapeutic failure: Patient's drug history uncertain 4.
Poor response to initial Rx or deterioration after good response 5. During drug interactions 7. Individualizing therapy and dosage regimen adjustment 8. To make decision about future therapy 9.
Pregnancy, age, weight 4.
Plasma protein binding 8. Digoxin toxicity vs ventricular arrhythmias: Maintena n ce costs of equipment: Active roles in patient care: How many times a day should samples can be sent for measurement? Suspected toxicity Compliance Therapeutic confirmation Absence of therapeutic response Please indicate when level is needed: Trough or predose level DateFifty human urine samples obtained from the forensic medicine institute chemistry laboratory in Cairo, Egypt, were screened by the Syva EMIT d.a.u.
urine cannabinoid assay with a . Summary. We compared results of theophylline, phenobarbital, and phenytoin assays by the EMIT® method using the IL Multistat III® Micro Centrifugal Analyzer with results by the EMIT semiautomated procedure on a Beckman 25 spectrophotometer equipped with a semiautomated pipettor-dilutor and a model automatic timer/printer.
Aminophylline and theophylline are medicines used to treat lung diseases such as asthma.
They help prevent and treat wheezing and other breathing problems. Aminophylline or theophylline overdose occurs when someone takes more than the normal or recommended amount of these medicines. This can be by accident or on . UV and EMIT (Figure 1 b) showed a slightly poorercorrelation,butaconsistenttrendforUVtogive higher levels than EMIT was the most obvious feature.
In some cases this was quite marked, the valueobtainedfromtheUVassay beingalmosttwice that from EMIT.
In particular, two samples shown by EMITand GLCto have negligible theophylline. Computer evaluation of the EMIT assays carbamazepine, ethosuximide, phenobarbital, phenytoin, quinidine and theophylline on the Gemsaec centrifugal fast analyser.
Analysis of urine and serum specimens from overdose patients was to optimize the EMIT assay such an optimization of the EMIT theophylline assay by modifying various instrumental and kit.